Submitted by hnapolitano on Sun, 04/26/2009 – 19:00
Many of my patients ask me this question. Most doctors will tell you “no”. There are 2 main reasons for this. First, very little about natural supplementation is taught in medical school. The second reason is because there are no “FDA” indications for the use of supplements in mental health. However, because so many patients have interest in this, I would like to share with you what I have seen be beneficial to some patients in my practice. Please keep in mind that this is only MY OPINION, based on MY EXPERIENCE. Most of the products mentioned below have some limited evidence of usefulness, but my suggestions are mostly based on what I have observed from my patients.
For Depression: Having said the above, there actually is good evidence that 5-HTP (5-hydroxytryptohan, which is basically Serotonin) can improve the sypmtoms of MILD Depression. I have seen this work in a number of patients, but again, only if that patient has presented with MILD Depressive symptoms. More often, I have seen it be beneficial by adding a small dose to an antidepressant. You see, antidepressants don’t actually increase the amount of serotonin in your brain. They only make your nerve cells use it better. So sometimes, if you’ve been on an antidepressant for a while and it stops working, it may be because your nerve cells are working so well they’ve used up all the serotinin and need more. I have also used 5-HTP to help in cases where a higher dose of an antidepressant has not been tolerated (because of side effects), to augment the effects of the antidepressant. Other benefits of 5-HTP: decreasing carbohydrate cravings, helping with mild anxiety and helping you sleep better.
*PLEASE DO NOT MIX ANTIDEPRESSANTS AND 5-HTP WITHOUT A DOCTOR’S ADVICE. This is because your body CAN get too much serotonin, resulting in something called serotonin syndrome, which can make you very sick!
My next recommendation for depression is not actually a supplement, but is something that is considered a “medical food” (that means you still have to have a prescription for it). The product is called Deplin. It is a methylated folate (folate is one of the B vitamins) tablet. It actually also has lots of evidence that indicate it helps depression get better faster and more completely, when added to an antidepressant. The fact that it is “methylated” means that it’s basically already in it’s usable form. It should be absorbed more easily and used more reeadily by your body than a regular folate tablet that you can buy over the counter. There are certain conditions where you would want to avoid extra folate, so you must speak to your doctor about this as well.
For Anxiety: The calming neurotransmitter, GABA, or Gamma-AminoButyric Acid, is a tyupical target of supplements that treat anxiety. In fact, the ones I have seen be beneficial are Theanine, an amino acid precursor to GABA, and simply taking GABA itself. Medications usch as Xanax, Valium, and Klonopin help anxiety by working on the GABA receptors. Sometimes adding GABA can help people reduce their need for one of the above medications, and sometimes helps with sleep as well. Please talk with your doctor before using this, because there are adverse effects from too much GABA!
Theanine (found in green tea) has many uses, and actually can increase levels of serotonin and dopamine, in addition to GABA. Ihave seen it be beneficial for mild anxiety by itsefl, or to help limit the dosage needed of an antianxiety medication. As a bonus, there is some evidence it enhances your body’s immune response to infection, and when added to caffeine, may increase cognition and mood (caffeine, however, is not recommended for anxiety and should be reduced in anxiety disorders). It is also usually an ingredient in over the counter “natural” sleep aids. While it is hard to get too much theanine, I would still only advise using it after consulting with a physician knowledgeable in the use of supplements.
Another product I have found useful in treating anxiety is Kavinace. This product is made by a company called Neuroscience. It contains 3 ingredients that all work to increase GABA production and activity. The first ingredient is phenibut, which is a derivative of GABA that actually gets into the nerve cells more easily than GABA. The second ingredient is Taurine, which is an amino acid that promotes the production of GABA and prevents the breakdown of GABA, therefore, making more available to your nerve cells. The final ingredient is B6, a vitamin which is needed in order for your body to make GABA. This product is useful on an “as needed” basis for anxiety, similar to the way one would use xanax, or also when taken regularly, usually 2 or 3 times a day, to help reduce overall tension, stress, or agitation, and sometimes hyperactivity. This product is only available through the Neuroscience company (an excellent company, in my opinion!), but many websites and physicians have collaborated with this company to make their products available.
AGAIN, FOR ALL SUPPLEMENTS, PLEASE ONLY USE AFTER TALKING WITH A PHYSICIAN KNOWLEDGEABLE IN THE USE OF SUPPLEMENTS; and be sure to disclose all your current medications and medical conditions, so the physician can make the most appropriate recommendations for you.
My only recommendations on brands of supplements are to try to find “pharmaceutical grade” products. I do have some of these things that I recommend available at our offices, and I am working to make more readily available at minimal costs.
Heidi Napolitano, M.D.
Psychiatrist